Jada Bascom Foundation
All conditions

Myeloproliferative neoplasms

Chronic neutrophilic leukemia

Also called: CNL · CSF3R-mutated CNL · myeloproliferative neoplasm · MPN · BCR::ABL1-negative chronic neutrophilic leukemia

Classified by the World Health Organization as Chronic neutrophilic leukaemia.

What a donor has to do with this

For some people with this condition, a transplant using blood stem cells from an unrelated donor is part of the treatment guidelines. When a transplant is the right route and no one in the family matches, that donor comes from a registry. Not everyone with this condition has a transplant, and many never need one.

This is our reading of published transplant guidelines for this condition, not a measurement of how many people need a donor. Where a source actually counted donors, the figure and the people it counted are shown further down. Where none did, we say so rather than estimate.

This page is not written out in full yet

We have not written this condition out in full yet. What is on this page — how a donor fits in, who it affects, and the sources behind that — is researched and linked, but the plain-English explanation of the condition itself is still to come.

What the evidence says

Who it affects
Typically diagnosed around age 65 and is markedly more common in men. Source population/region/year: international CNL literature synthesized in the Frontiers in Oncology review, published 2022.
Treatments other than a transplant
Hydroxyurea, interferon and ruxolitinib for CSF3R/JAK-STAT-driven disease; responses are often temporary and no non-HCT approach is established as curative
If a transplant is used, the cells come from
Allogeneic peripheral blood or bone marrow; matched unrelated donors predominate in one small Japanese nationwide series; cord-blood use was not reported in the opened disease-specific sources; dominant source not reported in the opened disease-specific sources
How often the donor was unrelated
Not reported. No source we could read states this for this condition, so we do not give a number. An estimate here would be a guess dressed as evidence.

Where this gets complicated

The exact donor-share estimate comes from a very small Japanese nationwide cohort and must not be generalized globally. Evidence is case-series level and older diagnostic criteria vary.

Written for transplant clinicians, not for patients. We quote it so you can see what the guidance actually says:
“Four patients received transplantation from matched-unrelated donors”

It describes what teams consider in general. It cannot say what applies to any one person. Read the source.

Registries need people

Joining a registry is a cheek swab and a short health form. You are not matched to a condition — you are matched to a person, and it could be someone with any of the conditions in this library. You are contacted only if you turn out to be a possible match for someone, and you can ask questions and decline before anything else happens.

Find your registry

Related conditions

Others in myeloproliferative neoplasms. They are genuinely different diseases with different treatments — the group name is not a diagnosis.

Where this came from

Chronic neutrophilic leukemia — what a bone marrow donor has to do with it | Jada Bascom Foundation