Condition group
Solid tumors
Cancers that form in tissues or organs. Stem cell transplantation has a role in selected cancers; it is not routine for most.
Conditions in this group
Grouped by the part transplant usually plays. Treatment depends on the exact diagnosis, disease stage, prior treatment and the person’s health.
Usually the person’s own cells 1
When transplant is used, it usually returns the person’s own cells after intensive treatment. This is called an autologous transplant; no donor is involved in that procedure.
Limited transplant role 13
Other treatments are usual. Transplant may be considered in selected circumstances or research settings, as described on the condition page.
- Condition overview
Atypical teratoid/rhabdoid tumor (AT/RT)
Atypical teratoid/rhabdoid tumor (AT/RT) is a rare, aggressive tumor of the brain or spinal cord, often associated with loss of SMARCB1 function or, less commonly, SMARCA4. Tissue and molecular testing guide diagnosis and may prompt genetic counseling.
Limited transplant role - Condition overview
Breast cancer
Breast cancer is a group of cancers arising in breast tissue. Stage and tumor features, including hormone-receptor and HER2 status, strongly influence treatment; it is not ordinarily a disease treated by replacing the marrow.
Limited transplant role - Condition overview
CNS germinoma (brain germinoma)
A CNS germinoma is a germ-cell tumor arising in the brain, often near the pineal or suprasellar regions. Its location can affect fluid circulation, vision or hormone function. It is treated differently from nongerminomatous CNS germ-cell tumors.
Limited transplant role - Condition overview
CNS nongerminomatous germ cell tumor (NGGCT)
CNS nongerminomatous germ-cell tumors are a varied group of brain tumors that includes several germ-cell histologies and mixed tumors. Imaging, tissue when appropriate and tumor markers distinguish them from pure germinoma and other brain tumors.
Limited transplant role - Condition overview
Ewing sarcoma
Ewing sarcoma is an aggressive cancer of bone or soft tissue, usually defined by a characteristic gene fusion. Treatment addresses both the visible tumor and the risk of disease elsewhere in the body.
Limited transplant role - Condition overview
Medulloblastoma
Medulloblastoma is a malignant brain tumor that begins in the cerebellum and can spread through cerebrospinal fluid. Molecular subgroup, age and disease spread help determine risk and treatment.
Limited transplant role - Condition overview
Ovarian germ cell tumor
Ovarian germ-cell tumors arise from cells in the ovary that normally develop into eggs. They include several tumor types and differ from the more common epithelial ovarian cancers.
Limited transplant role - Condition overview
Pineoblastoma
Pineoblastoma is a rare aggressive tumor of the pineal region of the brain. It can obstruct cerebrospinal fluid and spread within the central nervous system. Molecular subtype and age influence treatment and prognosis.
Limited transplant role - Condition overview
Primary mediastinal nonseminomatous germ cell tumor
Primary mediastinal nonseminomatous germ-cell tumor is a germ-cell cancer that begins in the chest between the lungs. It is distinct from a lymphoma and from a testicular tumor that has spread to the chest.
Limited transplant role - Condition overview
Retinoblastoma
Retinoblastoma is a cancer of the retina in young children. RB1-related genetic findings can affect one or both eyes and may have implications for family testing and future cancer risk.
Limited transplant role - Condition overview
Testicular nonseminoma (NSGCT)
Testicular nonseminomatous germ-cell tumors include several histologies, such as embryonal carcinoma, yolk-sac tumor, choriocarcinoma and teratoma, often in mixed tumors. Stage, tumor markers and the specific components guide treatment.
Limited transplant role - Condition overview
Testicular seminoma
Testicular seminoma is a germ-cell cancer that usually responds well to treatment. Pure seminoma is managed differently from nonseminomatous or mixed germ-cell tumors, so pathology and tumor markers matter.
Limited transplant role - Condition overview
Wilms tumor
Wilms tumor is a childhood kidney cancer. Stage, tissue findings, molecular features and whether one or both kidneys are affected help determine treatment; some children have an underlying genetic predisposition.
Limited transplant role
Other condition groups
Understanding transplant
Understanding can become action.
Some patients need a blood stem cell donor. Others receive different treatment. Wherever your interest began, you can help more people find the donor they need.
Join the registry
JBF points you to the official registry that serves your country. It explains who can join and what donation involves.
Help someone you love find a donor
If someone you love needs a donor, our family guide explains practical ways to help. A registration drive can add many potential donors at once, for them and for others.
Support this work
Gifts to the Jada Bascom Foundation support donor-awareness education like this page, community outreach, drive planning and referrals to official registries.
