Solid tumors
Ewing sarcoma
Ewing sarcoma is an aggressive cancer of bone or soft tissue, usually defined by a characteristic gene fusion. Treatment addresses both the visible tumor and the risk of disease elsewhere in the body.
Other names and abbreviations
Ewing's sarcoma · EWS · Ewing family tumor · Ewing tumor · peripheral primitive neuroectodermal tumour (historical when EWSR1-ETS fusion-defined)
Where transplant fits
Selected high-risk patients may receive high-dose chemotherapy with autologous stem cell rescue. The value of this approach depends on the specific setting; it is not routine for every Ewing sarcoma and normally uses the patient’s cells, not a registry donor.
Treatment depends on the exact diagnosis, disease stage, prior treatment and the person’s health. These categories are not estimates of donor demand.
Treatment at a glance
- Who it affects
- Ewing sarcoma mainly affects children, adolescents and young adults.
- Other treatment options
- Multi-drug chemotherapy is combined with surgery and/or radiation for local control. High-dose chemotherapy is used in selected high-risk settings, with choice guided by the protocol, disease extent and prior response.
- Cells used for transplantation
- The patient’s own collected blood-forming cells for autologous stem cell rescue, when that procedure is appropriate.
Questions to bring to your care team
What is the exact diagnosis or subtype? What is the goal of each treatment option? If transplant is being considered, why does it fit this situation, which cells would be used and what are the alternatives?
Sources and further reading
- Ewing Sarcoma Treatment (PDQ)
NCI · Accessed 2026-09-05 - Indications for haematopoietic cell transplantation and CAR-T: 2025 EBMT practice recommendations
EBMT / Bone Marrow Transplantation · Accessed 2026-09-05 - Stem Cell and Bone Marrow Transplants for Cancer
NCI · Accessed 2026-09-05
Understanding can become action.
Some patients need a blood stem cell donor. Others receive different treatment. Wherever your interest began, you can help JBF reach more people who may be able to donate.
Explore the official registry serving where you live. It explains who can join, how registration works and what donation involves.
Find your official registryIf joining is not right for you, a gift to the Jada Bascom Foundation supports education, outreach and referrals to official registries.
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