Condition group
Bone marrow failure
Conditions in which the marrow cannot produce enough healthy blood cells. Causes may be inherited or acquired.
Conditions in this group
Grouped by the part transplant usually plays. Treatment depends on the exact diagnosis, disease stage, prior treatment and the person’s health.
Donor transplant option 5
A transplant using a donor’s blood-forming cells is an established option for selected patients. A team may consider relatives, unrelated registry donors or cord blood, depending on the circumstances.
- In-depth guide
Congenital amegakaryocytic thrombocytopenia (MPL-related)
MPL-related congenital amegakaryocytic thrombocytopenia is a genetic disorder that causes too few platelets and can progress to broader marrow failure. A donor stem-cell transplant can restore blood production. Confirming the genetic cause matters because similar-looking conditions may need different treatment.
Donor transplant option - In-depth guide
Diamond-Blackfan anemia (DBA)
Diamond-Blackfan anemia, also called DBA syndrome, is a genetic condition that mainly reduces red-blood-cell production. Treatment may involve corticosteroids, transfusions with iron removal, or a donor transplant. Growth, congenital differences and cancer susceptibility also need attention.
Donor transplant option - In-depth guide
Dyskeratosis congenita (DC)
Dyskeratosis congenita is part of a group of genetic telomere biology disorders that can affect bone marrow, lungs, liver and other tissues. A donor transplant can treat severe marrow failure, but it does not correct the telomere disorder throughout the body.
Donor transplant option - In-depth guide
Fanconi anemia (FA)
Fanconi anemia is a genetic disorder of DNA repair that can affect blood production, growth and several organs, and increases cancer risk. A donor transplant can treat severe marrow failure and some blood cancers, but it does not correct the disorder throughout the body.
Donor transplant option - In-depth guide
Severe aplastic anemia (SAA)
Aplastic anemia is a serious failure of blood-cell production, usually caused by an immune attack on the bone marrow. It is not a cancer. Immunosuppressive treatment and a donor stem-cell transplant are both established approaches; the best route depends on the person and their available donors.
Donor transplant option
Limited transplant role 3
Other treatments are usual. Transplant may be considered in selected circumstances or research settings, as described on the condition page.
- In-depth guide
Paroxysmal nocturnal hemoglobinuria (PNH)
Paroxysmal nocturnal hemoglobinuria, or PNH, is an acquired blood disorder in which some blood cells lack protection from complement, part of the immune system. It can cause red-cell destruction and dangerous clots. Medicines usually lead treatment; donor transplantation has a selective role.
Limited transplant role - In-depth guide
Severe congenital neutropenia (SCN)
Severe congenital neutropenia is a group of genetic disorders that cause persistently low levels of neutrophils, white blood cells that help fight infection. Growth-factor treatment benefits many people. A donor transplant is considered when infection control or marrow findings make that the safer long-term option.
Limited transplant role - In-depth guide
Shwachman-Diamond syndrome (SDS)
Shwachman-Diamond syndrome is a genetic disorder that can affect the pancreas, blood production, growth and bones. Care often combines pancreatic enzymes, nutrition support and blood monitoring. A donor transplant treats serious marrow disease, while problems outside the blood system may persist.
Limited transplant role
Other condition groups
Understanding transplant
Understanding can become action.
Some patients need a blood stem cell donor. Others receive different treatment. Wherever your interest began, you can help more people find the donor they need.
Join the registry
JBF points you to the official registry that serves your country. It explains who can join and what donation involves.
Help someone you love find a donor
If someone you love needs a donor, our family guide explains practical ways to help. A registration drive can add many potential donors at once, for them and for others.
Support this work
Gifts to the Jada Bascom Foundation support donor-awareness education like this page, community outreach, drive planning and referrals to official registries.
