Condition group
Plasma cell disorders
Conditions of the antibody-making cells in the marrow. Most transplants here use the person’s own cells.
Conditions in this group
Grouped by the part transplant usually plays. Treatment depends on the exact diagnosis, disease stage, prior treatment and the person’s health.
Cell or gene therapy options 1
Cell or gene therapies may be options for eligible patients in some countries. They do not all work the same way, use the same cells or replace the same type of transplant.
Usually the person’s own cells 3
When transplant is used, it usually returns the person’s own cells after intensive treatment. This is called an autologous transplant; no donor is involved in that procedure.
- In-depth guide
AL amyloidosis (light-chain amyloidosis)
AL amyloidosis occurs when an abnormal cell clone produces antibody light chains that misfold and damage organs. Treatment suppresses that clone; some carefully selected patients receive high-dose chemotherapy followed by their own stem cells.
Usually the person’s own cells - In-depth guide
POEMS syndrome
POEMS syndrome is a rare disorder caused by an abnormal plasma-cell population, with nerve damage and effects on several organs. Treatment targets the plasma cells; an autologous stem cell transplant is an option for eligible people with systemic disease.
Usually the person’s own cells - In-depth guide
Primary plasma cell leukemia (pPCL)
Primary plasma cell leukemia is an aggressive plasma-cell cancer with malignant plasma cells circulating in blood at diagnosis. Treatment is urgent and often combines modern myeloma medicines with selected transplant strategies.
Usually the person’s own cells
Other condition groups
Understanding transplant
Understanding can become action.
Some patients need a blood stem cell donor. Others receive different treatment. Wherever your interest began, you can help more people find the donor they need.
Join the registry
JBF points you to the official registry that serves your country. It explains who can join and what donation involves.
Help someone you love find a donor
If someone you love needs a donor, our family guide explains practical ways to help. A registration drive can add many potential donors at once, for them and for others.
Support this work
Gifts to the Jada Bascom Foundation support donor-awareness education like this page, community outreach, drive planning and referrals to official registries.
