Inherited immune disorders
Leukocyte adhesion deficiency type I
Leukocyte adhesion deficiency type I is an ITGB2-related immune disorder that prevents white blood cells from moving normally from the bloodstream into infected tissues. Severe disease causes recurrent infections and poor wound healing.
Other names and abbreviations
LAD-I · LAD1 · ITGB2 deficiency · Integrin beta-2 deficiency · CD18 deficiency
Where transplant fits
Allogeneic transplantation can restore functional donor immune cells. In the US, Kresladi is an autologous gene-therapy option for specified children with severe ITGB2-related LAD-I without an available HLA-matched sibling donor; it does not require a registry donor.
Treatment depends on the exact diagnosis, disease stage, prior treatment and the person’s health. These categories are not estimates of donor demand.
Treatment at a glance
- Who it affects
- Severe disease often becomes evident in infancy. Milder ITGB2-related disease can have a different course.
- Other treatment options
- Antimicrobial care, wound management and definitive-treatment assessment are central. The FDA indication and prescribing information govern Kresladi eligibility and follow-up.
- Cells used for transplantation
- Donor stem cells for allogeneic transplantation; the patient’s own gene-modified stem cells for eligible autologous gene therapy.
Why the details matter
Kresladi has accelerated approval, and availability is country specific. Gene therapy still involves conditioning and long-term safety monitoring; it should not be generalized to LAD types II or III.
Questions to bring to your care team
What is the exact diagnosis or subtype? What is the goal of each treatment option? If transplant is being considered, why does it fit this situation, which cells would be used and what are the alternatives?
Sources and further reading
- KRESLADI: indication and current prescribing information
FDA · Accessed 2026-09-05 - Guidelines for hematopoietic stem cell transplantation for inborn errors of immunity
EBMT / ESID Inborn Errors Working Party · 2021
Understanding can become action.
Some patients need a blood stem cell donor. Others receive different treatment. Wherever your interest began, you can help JBF reach more people who may be able to donate.
Explore the official registry serving where you live. It explains who can join, how registration works and what donation involves.
Find your official registryIf joining is not right for you, a gift to the Jada Bascom Foundation supports education, outreach and referrals to official registries.
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