Jada Bascom Foundation
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Autoimmune conditions

Chronic inflammatory demyelinating polyradiculoneuropathy

Also called: CIDP · chronic immune demyelinating neuropathy · immune-mediated polyradiculoneuropathy · Chronic inflammatory demyelinating polyneuropathy · Chronic relapsing inflammatory polyneuropathy

What a donor has to do with this

A transplant is not a standard part of treating this condition. It is used rarely, in particular situations, and most people diagnosed with it will not have one.

This is our reading of published transplant guidelines for this condition, not a measurement of how many people need a donor. Where a source actually counted donors, the figure and the people it counted are shown further down. Where none did, we say so rather than estimate.

What the evidence says

Who it affects
In the Dutch population-based cohort published in 2022, chronic inflammatory demyelinating polyradiculoneuropathy had a median diagnosis age of 58, 66% of patients were male, and incidence was 17-fold higher at age 50 or older than below 50.
Treatments other than a transplant
IVIg or corticosteroids are strongly recommended first-line; plasma exchange is recommended when they fail, and SCIg is used for maintenance.; Efgartigimod alfa/hyaluronidase/Vyvgart Hytrulo became a US-approved adult CIDP option in 2024.; Immunosuppressive or biologic rescue is individualized when guideline therapies fail.
If a transplant is used, the cells come from
autologous mobilized peripheral-blood stem cells (dominant contemporary source); bone marrow: not reported in the opened disease-specific sources; cord blood: not reported in the opened disease-specific sources
How often the donor was unrelated
Not reported. No source we could read states this for this condition, so we do not give a number. An estimate here would be a guess dressed as evidence.

Where this gets complicated

Uncontrolled series report improvement, but there is no definitive randomized comparison with modern maintenance IVIg/SCIg, FcRn blockade, or other rescue therapy.; CIDP misdiagnosis is common in treatment-refractory referrals; transplant candidacy requires rigorous electrodiagnostic and clinical confirmation.; EBMT says clinical option, not standard of care; long-term relapse, neuropathy reversibility, infertility, infection, and secondary-autoimmunity risks remain relevant.

Written for transplant clinicians, not for patients. We quote it so you can see what the guidance actually says:
“Currently hematopoietic stem cell transplantation is used for refractory CIDP patients.”

It describes what teams consider in general. It cannot say what applies to any one person. Read the source.

We are not asking you to register on this page

An unrelated donor is not a usual part of treating this condition, so it would be dishonest to use this page to ask you to register. Other conditions in the library are a different story.

Related conditions

Others in autoimmune conditions. They are genuinely different diseases with different treatments — the group name is not a diagnosis.

Where this came from

Chronic inflammatory demyelinating polyradiculoneuropathy — what it is and how it is treated | Jada Bascom Foundation